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ATP-Bound Conformation of Topoisomerase IV: a Possible Target for Quinolones in Streptococcus pneumoniae

Topoisomerase IV, a C(2)E(2) tetramer, is involved in the topological changes of DNA during replication. This enzyme is the target of antibacterial compounds, such as the coumarins, which target the ATP binding site in the ParE subunit, and the quinolones, which bind, outside the active site, to the...

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書誌詳細
主要な著者: Sifaoui, Farid, Lamour, Valérie, Varon, Emmanuelle, Moras, Dino, Gutmann, Laurent
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC225018/
https://ncbi.nlm.nih.gov/pubmed/14526026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.20.6137-6146.2003
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