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Genetic selection for protein solubility enabled by the folding quality control feature of the twin-arginine translocation pathway

One of the most vexing problems facing structural genomics efforts and the biotechnology enterprise in general is the inability to efficiently produce functional proteins due to poor folding and insolubility. Additionally, protein misfolding and aggregation has been linked to a number of human disea...

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Bibliografski detalji
Glavni autori: Fisher, Adam C., Kim, Woojin, Delisa, Matthew P.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2249766/
https://ncbi.nlm.nih.gov/pubmed/16452624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051902606
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