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Adaptor SKAP-55 Binds p21(ras) Activating Exchange Factor RasGRP1 and Negatively Regulates the p21(ras)-ERK Pathway in T-Cells
While the adaptor SKAP-55 mediates LFA-1 adhesion on T-cells, it is not known whether the adaptor regulates other aspects of signaling. SKAP-55 could potentially act as a node to coordinate the modulation of adhesion with downstream signaling. In this regard, the GTPase p21(ras) and the extracellula...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2249700/ https://ncbi.nlm.nih.gov/pubmed/18320039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001718 |
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