Adaptor SKAP-55 Binds p21(ras) Activating Exchange Factor RasGRP1 and Negatively Regulates the p21(ras)-ERK Pathway in T-Cells

While the adaptor SKAP-55 mediates LFA-1 adhesion on T-cells, it is not known whether the adaptor regulates other aspects of signaling. SKAP-55 could potentially act as a node to coordinate the modulation of adhesion with downstream signaling. In this regard, the GTPase p21(ras) and the extracellula...

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Detalhes bibliográficos
Main Authors: Schneider, Helga, Wang, Hongyan, Raab, Monika, Valk, Elke, Smith, Xin, Lovatt, Matt, Wu, Zhonglin, Maqueira-Iglesias, Braudel, Strebhardt, Klaus, Rudd, Christopher E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2249700/
https://ncbi.nlm.nih.gov/pubmed/18320039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001718
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