The presence of the TAR RNA structure alters the programmed -1 ribosomal frameshift efficiency of the human immunodeficiency virus type 1 (HIV-1) by modifying the rate of translation initiation

HIV-1 uses a programmed -1 ribosomal frameshift to synthesize the precursor of its enzymes, Gag-Pol. The frameshift efficiency that is critical for the virus replication, is controlled by an interaction between the ribosome and a specific structure on the viral mRNA, the frameshift stimulatory signa...

Full description

Saved in:
Bibliographic Details
Main Authors: Gendron, Karine, Charbonneau, Johanie, Dulude, Dominic, Heveker, Nikolaus, Ferbeyre, Gerardo, Brakier-Gingras, Léa
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248755/
https://ncbi.nlm.nih.gov/pubmed/17984074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm906
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items