The presence of the TAR RNA structure alters the programmed -1 ribosomal frameshift efficiency of the human immunodeficiency virus type 1 (HIV-1) by modifying the rate of translation initiation

HIV-1 uses a programmed -1 ribosomal frameshift to synthesize the precursor of its enzymes, Gag-Pol. The frameshift efficiency that is critical for the virus replication, is controlled by an interaction between the ribosome and a specific structure on the viral mRNA, the frameshift stimulatory signa...

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Detalhes bibliográficos
Main Authors: Gendron, Karine, Charbonneau, Johanie, Dulude, Dominic, Heveker, Nikolaus, Ferbeyre, Gerardo, Brakier-Gingras, Léa
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248755/
https://ncbi.nlm.nih.gov/pubmed/17984074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm906
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