Troponin and Titin Coordinately Regulate Length-dependent Activation in Skinned Porcine Ventricular Muscle

We investigated the molecular mechanism by which troponin (Tn) regulates the Frank-Starling mechanism of the heart. Quasi-complete reconstitution of thin filaments with rabbit fast skeletal Tn (sTn) attenuated length-dependent activation in skinned porcine left ventricular muscle, to a magnitude sim...

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Hauptverfasser: Terui, Takako, Sodnomtseren, Munguntsetseg, Matsuba, Douchi, Udaka, Jun, Ishiwata, Shin'ichi, Ohtsuki, Iwao, Kurihara, Satoshi, Fukuda, Norio
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248715/
https://ncbi.nlm.nih.gov/pubmed/18299397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200709895
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