The Meningococcal Vaccine Candidate GNA1870 Binds the Complement Regulatory Protein Factor H and Enhances Serum Resistance

Neisseria meningitidis binds factor H (fH), a key regulator of the alternative complement pathway. A ~29 kD fH-binding protein expressed in the meningococcal outer membrane was identified by mass spectrometry as GNA1870, a lipoprotein currently under evaluation as a broad-spectrum meningococcal vacc...

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Autori principali: Madico, Guillermo, Welsch, Jo Anne, Lewis, Lisa A., McNaughton, Anne, Perlman, David H., Costello, Catherine E., Ngampasutadol, Jutamas, Vogel, Ulrich, Granoff, Dan M., Ram, Sanjay
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248442/
https://ncbi.nlm.nih.gov/pubmed/16785547
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