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Enhancement of coenzyme binding by a single point mutation at the coenzyme binding domain of E. coli lactaldehyde dehydrogenase

Phenylacetaldehyde dehydrogenase (PAD) and lactaldehyde dehydrogenase (ALD) share some structural and kinetic properties. One difference is that PAD can use NAD(+) and NADP(+), whereas ALD only uses NAD(+). An acidic residue has been involved in the exclusion of NADP(+) from the active site in pyrid...

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Bibliografiske detaljer
Hovedforfatter: Rodríguez-Zavala, José Salud
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248313/
https://ncbi.nlm.nih.gov/pubmed/18218709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073277108
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