Partial protection of oncogene, anti-sense oligodeoxynucleotides against serum nuclease degradation using terminal methylphosphonate groups.

Under certain circumstances sequence-specific inhibition of gene expression may be achieved in intact cells using exogenous anti-sense oligodeoxynucleotides. The efficacy of this approach to investigating gene function is limited in part by the rapid serum nuclease mediated degradation of oligodeoxy...

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Bibliographic Details
Main Authors: Tidd, D. M., Warenius, H. M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1989
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2247198/
https://ncbi.nlm.nih.gov/pubmed/2551358
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