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Interaction of the novel agent amphethinile with tubulin.

The novel agent amphethinile is shown to inhibit tubulin assembly in vitro. This agent is capable of displacing colchicine but not vinblastine from tubulin and causes a stimulation in GTPase activity in vitro. The affinity constant for the association of this drug with tubulin has been determined (K...

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Autors principals: McGown, A. T., Fox, B. W.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1989
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246728/
https://ncbi.nlm.nih.gov/pubmed/2736224
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