A phase I and pharmacokinetic study of amphethinile.

Amphethinile is a new spindle poison with a novel structure that has shown activity in the L1210, ADJ/PC6 and Walker carcinoma rodent tumours. In addition the agent appeared to have an improved therapeutic ratio compared to existing spindle poisons and is well absorbed when administered orally. The...

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Autori principali: Smith, D. B., Ewen, C., Mackintosh, J., Fox, B. W., Thatcher, N., Scarffe, J. H., Vezin, R., Crowther, D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1988
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246468/
https://ncbi.nlm.nih.gov/pubmed/3408647
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