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Pentamethylmelamine (PMM): Phase I clinical and pharmacokinetic studies.

PMM is a water-soluble alternative to HMM. PMM has been administered as an intravenous infusion to 17 patients in a Phase I clinical trial. The dose-limiting toxicities were nausea and vomiting which were observed in all patients at 500 mg m-2 and above. The dose was not escalated above 1300 mg m-2...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Muindi, J. R., Newell, D. R., Smith, I. E., Harrap, K. R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1983
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2011259/
https://ncbi.nlm.nih.gov/pubmed/6401427
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