Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation

The angiotensin II type 1 (AT(1)) receptor is a G protein-coupled receptor that has a crucial role in the development of load-induced cardiac hypertrophy. Here, we show that cell stretch leads to activation of the AT(1) receptor, which undergoes an anticlockwise rotation and a shift of transmembrane...

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Detalhes bibliográficos
Main Authors: Yasuda, Noritaka, Miura, Shin-ichiro, Akazawa, Hiroshi, Tanaka, Toshimasa, Qin, Yingjie, Kiya, Yoshihiro, Imaizumi, Satoshi, Fujino, Masahiro, Ito, Kaoru, Zou, Yunzeng, Fukuhara, Shigetomo, Kunimoto, Satoshi, Fukuzaki, Koichi, Sato, Toshiaki, Ge, Junbo, Mochizuki, Naoki, Nakaya, Haruaki, Saku, Keijiro, Komuro, Issei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246415/
https://ncbi.nlm.nih.gov/pubmed/18202720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7401157
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