A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases

The non-hydrolysing bacterial UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) catalyses the conversion of UDP-GlcNAc into UDP-N-acetylmannosamine, an intermediate in the biosynthesis of several cell-surface polysaccharides. This enzyme is allosterically regulated by its substrate UDP-Gl...

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Main Authors: Velloso, Lucas M, Bhaskaran, Shyam S, Schuch, Raymond, Fischetti, Vincent A, Stebbins, C Erec
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
Teme:
Scientific Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246411/
https://ncbi.nlm.nih.gov/pubmed/18188181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7401154
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