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Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools

BACKGROUND: The phenomenon of functional site turnover has important implications for the study of regulatory region evolution, such as for promoter sequence alignments and transcription factor binding site (TFBS) identification. At present, it remains difficult to estimate TFBS turnover rates on re...

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Bibliografske podrobnosti
Main Authors: Huang, Weichun, Nevins, Joseph R, Ohler, Uwe
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246299/
https://ncbi.nlm.nih.gov/pubmed/17956628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-10-r225
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