Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer

INTRODUCTION: Hypoxia-inducible factor (HIF)-1α levels in invasive breast carcinoma have been shown to be an adverse prognostic indicator. Cellular HIF-1α activity is regulated by factor-inhibiting hypoxia-inducible factor 1 (FIH-1). In hypoxia, FIH-1 hydroxylation of Asn803 within the C-terminal tr...

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Main Authors: Tan, Ern Yu, Campo, Leticia, Han, Cheng, Turley, Helen, Pezzella, Francesco, Gatter, Kevin C, Harris, Adrian L, Fox, Stephen B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246192/
https://ncbi.nlm.nih.gov/pubmed/18096060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1838
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