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Vaccinia Virus Interleukin-18-Binding Protein Promotes Virulence by Reducing Gamma Interferon Production and Natural Killer and T-Cell Activity
Interleukin-18 (IL-18) is a proinflammatory cytokine that promotes natural killer (NK) and T-cell activation. Several poxviruses, including vaccinia virus (VV), encode a soluble IL-18-binding protein (IL-18bp). The role of the VV IL-18bp (gene C12L) in vivo was studied with wild-type (vC12L), deleti...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2003
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC224600/ https://ncbi.nlm.nih.gov/pubmed/12941906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.18.9960-9968.2003 |
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