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Anakinra Pilot – a clinical trial to demonstrate safety, feasibility and pharmacokinetics of interleukin 1 receptor antagonist in preterm infants

BackgroundBronchopulmonary dysplasia (BPD), its complication pulmonary hypertension (BPD-PH) and preterm brain and gut injury lead to significant morbidity and mortality in infants born extremely prematurely. There is extensive evidence that the pro-inflammatory cytokine interleukin 1 (IL-1) plays a...

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Kaydedildi:
Asıl Yazarlar: Elys A. Green, David Metz, Robert Galinsky, Rebecka Atkinson, Elizbeth M. Skuza, Megan Clark, Alistair J Gunn, Carl M. Kirkpatrick, Rod W. Hunt, Philip J. Berger, Claudia A. Nold-Petry, Marcel F. Nold
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2022-10-01
Seri Bilgileri:Frontiers in Immunology
Konular:
preterm infant
inflammation
anti-inflammatory therapy
interleukin 1 receptor antagonist
clinical trial
translational research
Online Erişim:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022104/full
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