Anakinra Pilot – a clinical trial to demonstrate safety, feasibility and pharmacokinetics of interleukin 1 receptor antagonist in preterm infants

BackgroundBronchopulmonary dysplasia (BPD), its complication pulmonary hypertension (BPD-PH) and preterm brain and gut injury lead to significant morbidity and mortality in infants born extremely prematurely. There is extensive evidence that the pro-inflammatory cytokine interleukin 1 (IL-1) plays a...

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Hlavní autoři:	Elys A. Green, David Metz, Robert Galinsky, Rebecka Atkinson, Elizbeth M. Skuza, Megan Clark, Alistair J Gunn, Carl M. Kirkpatrick, Rod W. Hunt, Philip J. Berger, Claudia A. Nold-Petry, Marcel F. Nold
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-10-01
Edice:	Frontiers in Immunology
Témata:	preterm infant inflammation anti-inflammatory therapy interleukin 1 receptor antagonist clinical trial translational research
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022104/full
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