Vaccinia Virus Interleukin-18-Binding Protein Promotes Virulence by Reducing Gamma Interferon Production and Natural Killer and T-Cell Activity

Interleukin-18 (IL-18) is a proinflammatory cytokine that promotes natural killer (NK) and T-cell activation. Several poxviruses, including vaccinia virus (VV), encode a soluble IL-18-binding protein (IL-18bp). The role of the VV IL-18bp (gene C12L) in vivo was studied with wild-type (vC12L), deleti...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Reading, Patrick C., Smith, Geoffrey L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC224600/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12941906/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.18.9960-9968.2003
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