Genetic Deficiency of Glycogen Synthase Kinase-3β Corrects Diabetes in Mouse Models of Insulin Resistance

Despite treatment with agents that enhance β-cell function and insulin action, reduction in β-cell mass is relentless in patients with insulin resistance and type 2 diabetes mellitus. Insulin resistance is characterized by impaired signaling through the insulin/insulin receptor/insulin receptor subs...

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Main Authors: Tanabe, Katsuya, Liu, Zhonghao, Patel, Satish, Doble, Bradley W, Li, Lin, Cras-Méneur, Corentin, Martinez, Sara C, Welling, Cris M, White, Morris F, Bernal-Mizrachi, Ernesto, Woodgett, James R, Permutt, M. Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2245985/
https://ncbi.nlm.nih.gov/pubmed/18288891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060037
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