Glucose and Fatty Acids Synergize to Promote B-Cell Apoptosis through Activation of Glycogen Synthase Kinase 3β Independent of JNK Activation

BACKGROUND: The combination of elevated glucose and free-fatty acids (FFA), prevalent in diabetes, has been suggested to be a major contributor to pancreatic β-cell death. This study examines the synergistic effects of glucose and FFA on β-cell apoptosis and the molecular mechanisms involved. Mouse...

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Auteurs principaux: Tanabe, Katsuya, Liu, Yang, Hasan, Syed D., Martinez, Sara C., Cras-Méneur, Corentin, Welling, Cris M., Bernal-Mizrachi, Ernesto, Tanizawa, Yukio, Rhodes, Christopher J., Zmuda, Erik, Hai, Tsonwin, Abumrad, Nada A., Permutt, M. Alan
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082528/
https://ncbi.nlm.nih.gov/pubmed/21541314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018146
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