Enhanced Mucosal Immunoglobulin A Response of Intranasal Adenoviral Vector Human Immunodeficiency Virus Vaccine and Localization in the Central Nervous System

Replication-defective adenovirus (ADV) vectors represent a promising potential platform for the development of a vaccine for AIDS. Although this vector is typically administered intramuscularly, it would be desirable to induce mucosal immunity by delivery through alternative routes. In this study, t...

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Autors principals: Lemiale, Franck, Kong, Wing-pui, Akyürek, Levent M., Ling, Xu, Huang, Yue, Chakrabarti, Bimal K., Eckhaus, Michael, Nabel, Gary J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC224584/
https://ncbi.nlm.nih.gov/pubmed/12941918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.18.10078-10087.2003
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