Overcoming Immunity to a Viral Vaccine by DNA Priming before Vector Boosting

Replication-defective adenovirus (ADV) and poxvirus vectors have shown potential as vaccines for pathogens such as Ebola or human immunodeficiency virus in nonhuman primates, but prior immunity to the viral vector in humans may limit their clinical efficacy. To overcome this limitation, the effect o...

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Detalhes bibliográficos
Main Authors: Yang, Zhi-yong, Wyatt, Linda S., Kong, Wing-pui, Moodie, Zoe, Moss, Bernard, Nabel, Gary J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140625/
https://ncbi.nlm.nih.gov/pubmed/12477888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.1.799-803.2003
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