Overcoming Immunity to a Viral Vaccine by DNA Priming before Vector Boosting

Replication-defective adenovirus (ADV) and poxvirus vectors have shown potential as vaccines for pathogens such as Ebola or human immunodeficiency virus in nonhuman primates, but prior immunity to the viral vector in humans may limit their clinical efficacy. To overcome this limitation, the effect o...

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Главные авторы: Yang, Zhi-yong, Wyatt, Linda S., Kong, Wing-pui, Moodie, Zoe, Moss, Bernard, Nabel, Gary J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2003
Предметы:
Vaccines and Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC140625/
https://ncbi.nlm.nih.gov/pubmed/12477888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.1.799-803.2003
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