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A single point mutation in the pore region of the epithelial Na(+) channel changes ion selectivity by modifying molecular sieving

The epithelial Na(+) channel (ENaC) belongs to a new class of channel proteins called the ENaC/DEG superfamily involved in epithelial Na(+) transport, mechanotransduction, and neurotransmission. The role of ENaC in Na(+) homeostasis and in the control of blood pressure has been demonstrated recently...

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Bibliografiske detaljer
Main Authors: Kellenberger, Stephan, Gautschi, Ivan, Schild, Laurent
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC22439/
https://ncbi.nlm.nih.gov/pubmed/10097182
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