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An Immortalized Human Cell Line Bearing a PRKAR1A-Inactivating Mutation: Effects of Overexpression of the Wild-Type Allele and Other Protein Kinase A Subunits

Context: Inactivating mutations of PRKAR1A, the regulatory subunit type 1A (RIα) of protein kinase A (PKA), are associated with tumor formation. Objective: Our objective was to evaluate the role of PKA isozymes on proliferation and cell cycle. Methods: A cell line with RIα haploinsufficiency due to...

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Bibliografiske detaljer
Main Authors: Nesterova, Maria, Bossis, Ioannis, Wen, Feng, Horvath, Anelia, Matyakhina, Ludmila, Stratakis, Constantine A.
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2243228/
https://ncbi.nlm.nih.gov/pubmed/18056771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2007-1902
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