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Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling
BACKGROUND: O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also possesses a chaperone activity that promotes the folding and secretion of No...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2242781/ https://ncbi.nlm.nih.gov/pubmed/18194540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-6-1 |
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