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Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins

EGFR and Hippo signaling both control growth, and when dysregulated contribute to tumorigenesis. We find that EGFR activates the Hippo pathway transcription factor Yorkie, and demonstrate that Yorkie is required for the influence of EGFR on cell proliferation in Drosophila. EGFR regulates Yorkie thr...

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Bibliografiske detaljer
Main Authors: Reddy, B.V.V.G., Irvine, Kenneth D.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624988/
https://ncbi.nlm.nih.gov/pubmed/23484853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.01.020
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