Učitavanje...
Allosteric effects in the marginally stable von Hippel–Lindau tumor suppressor protein and allostery-based rescue mutant design
Many multifunctional tumor suppressor proteins have low stability, a property linked to cancer development. The von Hippel–Lindau tumor suppressor protein (pVHL) is one of these proteins. pVHL forms part of the E3 ubiquitin ligase complex that regulates the degradation of the hypoxia-inducible facto...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2008
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2242715/ https://ncbi.nlm.nih.gov/pubmed/18195360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707401105 |
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