PPARα agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition

Angiogenesis and inflammation are central processes through which the tumor microenvironment influences tumor growth. We have demonstrated recently that peroxisome proliferator-activated receptor (PPAR)α deficiency in the host leads to overt inflammation that suppresses angiogenesis via excess produ...

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Hauptverfasser: Panigrahy, Dipak, Kaipainen, Arja, Huang, Sui, Butterfield, Catherine E., Barnés, Carmen M., Fannon, Michael, Laforme, Andrea M., Chaponis, Deviney M., Folkman, Judah, Kieran, Mark W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242705/
https://ncbi.nlm.nih.gov/pubmed/18199835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711281105
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