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Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages

Phagocytes generate nitric oxide (NO) and other reactive oxygen and nitrogen species in large quantities to combat infecting bacteria. Here, we report the surprising observation that in vivo survival of a notorious pathogen—Bacillus anthracis—critically depends on its own NO-synthase (bNOS) activity...

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Hlavní autoři: Shatalin, Konstantin, Gusarov, Ivan, Avetissova, Ekaterina, Shatalina, Yelena, McQuade, Lindsey E., Lippard, Stephen J., Nudler, Evgeny
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242674/
https://ncbi.nlm.nih.gov/pubmed/18215992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710950105
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