Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation

The activation of initiator protein tissue factor (TF) is likely to be a crucial step in the blood coagulation process, which leads to fibrin formation. The stimuli responsible for inducing TF activation are largely undefined. Here we show that the oxidoreductase protein disulfide isomerase (PDI) di...

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Detalhes bibliográficos
Main Authors: Reinhardt, Christoph, von Brühl, Marie-Luise, Manukyan, Davit, Grahl, Lenka, Lorenz, Michael, Altmann, Berid, Dlugai, Silke, Hess, Sonja, Konrad, Ildiko, Orschiedt, Lena, Mackman, Nigel, Ruddock, Lloyd, Massberg, Steffen, Engelmann, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242616/
https://ncbi.nlm.nih.gov/pubmed/18274674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32376
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