Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation

The activation of initiator protein tissue factor (TF) is likely to be a crucial step in the blood coagulation process, which leads to fibrin formation. The stimuli responsible for inducing TF activation are largely undefined. Here we show that the oxidoreductase protein disulfide isomerase (PDI) di...

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Bibliografske podrobnosti
Main Authors: Reinhardt, Christoph, von Brühl, Marie-Luise, Manukyan, Davit, Grahl, Lenka, Lorenz, Michael, Altmann, Berid, Dlugai, Silke, Hess, Sonja, Konrad, Ildiko, Orschiedt, Lena, Mackman, Nigel, Ruddock, Lloyd, Massberg, Steffen, Engelmann, Bernd
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242616/
https://ncbi.nlm.nih.gov/pubmed/18274674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32376
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