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Engineered lanthanide-binding metallohomeodomains: Designing folded chimeras by modular turn substitution
A series of chimeric metallohomeodomains are described, engineered by rational design of a flexible Ca/Ln binding site into a DNA-binding scaffold. A modular turn-substitution approach was used to create proteins that both bind DNA and lanthanide ions, while retaining the secondary structure of the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2242603/ https://ncbi.nlm.nih.gov/pubmed/16943445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062365506 |
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