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The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg(2+) supports an associative mechanism for phosphoryl transfer
The crystal structure of Mycobacterium tuberculosis adenylate kinase (MtAK) in complex with two ADP molecules and Mg(2+) has been determined at 1.9 Å resolution. Comparison with the solution structure of the enzyme, obtained in the absence of substrates, shows significant conformational changes of t...
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| Glavni autori: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2006
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2242552/ https://ncbi.nlm.nih.gov/pubmed/16672241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062163406 |
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