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The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg(2+) supports an associative mechanism for phosphoryl transfer

The crystal structure of Mycobacterium tuberculosis adenylate kinase (MtAK) in complex with two ADP molecules and Mg(2+) has been determined at 1.9 Å resolution. Comparison with the solution structure of the enzyme, obtained in the absence of substrates, shows significant conformational changes of t...

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Bibliografiske detaljer
Main Authors: Bellinzoni, Marco, Haouz, Ahmed, Graña, Martin, Munier-Lehmann, Hélène, Shepard, William, Alzari, Pedro M.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242552/
https://ncbi.nlm.nih.gov/pubmed/16672241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062163406
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