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Selection of allosteric β-lactamase mutants featuring an activity regulation by transition metal ions
Libraries of phage-displayed β-lactamase mutants in which up to three loops have been engineered by genetic introduction of random peptide sequences or by randomization of the wild-type sequence have been submitted to selection protocols designed to find mutants in which binding of transition metal...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Cold Spring Harbor Laboratory Press
2006
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2242392/ https://ncbi.nlm.nih.gov/pubmed/16963642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062304406 |
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