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Selection of allosteric β-lactamase mutants featuring an activity regulation by transition metal ions

Libraries of phage-displayed β-lactamase mutants in which up to three loops have been engineered by genetic introduction of random peptide sequences or by randomization of the wild-type sequence have been submitted to selection protocols designed to find mutants in which binding of transition metal...

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Detalhes bibliográficos
Main Authors: Mathonet, Pascale, Barrios, Humberto, Soumillion, Patrice, Fastrez, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242392/
https://ncbi.nlm.nih.gov/pubmed/16963642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062304406
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