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A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP
Cyclic AMP activates protein kinase A by binding to an inhibitory regulatory (R) subunit and releasing inhibition of the catalytic (C) subunit. Even though crystal structures of regulatory and catalytic subunits have been solved, the precise molecular mechanism by which cyclic AMP activates the kina...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2242374/ https://ncbi.nlm.nih.gov/pubmed/16322564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051723606 |
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