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A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP

Cyclic AMP activates protein kinase A by binding to an inhibitory regulatory (R) subunit and releasing inhibition of the catalytic (C) subunit. Even though crystal structures of regulatory and catalytic subunits have been solved, the precise molecular mechanism by which cyclic AMP activates the kina...

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Bibliografiske detaljer
Main Authors: Vigil, Dominico, Lin, Jung-Hsin, Sotriffer, Christoph A., Pennypacker, Juniper K., McCammon, J. Andrew, Taylor, Susan S.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242374/
https://ncbi.nlm.nih.gov/pubmed/16322564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051723606
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