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Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon

RNA interference (RNAi) mediated by small-interfering RNAs (siRNAs) is a highly effective gene-silencing mechanism with great potential for gene-therapeutic applications. siRNA agents also exert non-target-related biological effects and toxicities, including immune-system stimulation. Specifically,...

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Detalhes bibliográficos
Main Authors: Gondai, Takuma, Yamaguchi, Kazuya, Miyano-Kurosaki, Naoko, Habu, Yuichirou, Takaku, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2241887/
https://ncbi.nlm.nih.gov/pubmed/18208841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1043
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