CD40 Ligand/Trimer DNA Enhances Both Humoral and Cellular Immune Responses and Induces Protective Immunity to Infectious and Tumor Challenge

CD40/CD40 ligand interactions have a central role in the induction of both humoral and cellular immunity. In this study, we examined whether a plasmid expressing CD40 ligand/trimer (CD40LT) could enhance immune responses in vivo. BALB/c mice were injected with plasmid expressing β-galactosidase DNA...

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Detalhes bibliográficos
Main Authors: Gurunathan, Sanjay, Irvine, Kari R., Wu, Chang-You, Cohen, Jeffrey I., Thomas, Elaine, Prussin, Calman, Restifo, Nicholas P., Seder, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2239005/
https://ncbi.nlm.nih.gov/pubmed/9794383
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