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Immunity to a Self-Derived, Channel-Forming Peptide in the Respiratory Tract

The channel-forming peptide NC-1130 was generated based on the amino acid sequence of the M2 segment of the spinal cord α-subunit of the glycine receptor and has been proposed as a therapeutic agent for anion channelopathies such as cystic fibrosis. Lysine adduction and amino acid substitutions at p...

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Bibliographic Details
Main Authors: van Ginkel, Frederik W., Iwamoto, Takeo, Schultz, Bruce D., Tomich, John M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2238045/
https://ncbi.nlm.nih.gov/pubmed/18094111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00319-07
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