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Isolation of a human single chain antibody fragment against oligomeric α-synuclein that inhibits aggregation and prevents α-synuclein induced toxicity
Protein misfolding and aggregation are pathological aspects of numerous neurodegenerative diseases. Aggregates of α-synuclein are major components of the Lewy bodies and Lewy neurites associated with Parkinson’s Disease (PD). A natively unfolded protein, α-synuclein can adopt different aggregated mo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2235820/ https://ncbi.nlm.nih.gov/pubmed/17391701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.089 |
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