Isolation of a human single chain antibody fragment against oligomeric α-synuclein that inhibits aggregation and prevents α-synuclein induced toxicity

Protein misfolding and aggregation are pathological aspects of numerous neurodegenerative diseases. Aggregates of α-synuclein are major components of the Lewy bodies and Lewy neurites associated with Parkinson’s Disease (PD). A natively unfolded protein, α-synuclein can adopt different aggregated mo...

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Hlavní autoři: Emadi, Sharareh, Barkhordarian, Hedieh, Wang, Min S., Schulz, Philip, Sierks, Michael R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2235820/
https://ncbi.nlm.nih.gov/pubmed/17391701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.089
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