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Vascular Endothelial Growth Factor Receptor-2 Expression Is Down-Regulated by 17β-Estradiol in MCF-7 Breast Cancer Cells by Estrogen Receptor α/Sp Proteins

17β-Estradiol (E2) induces and represses gene expression in breast cancer cells; however, the mechanisms of gene repression are not well understood. In this study, we show that E2 decreases vascular endothelial growth factor receptor 2 (VEGFR2) mRNA levels in MCF-7 cells, and this gene was used as a...

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Detalhes bibliográficos
Main Authors: Higgins, Kelly J., Liu, Shengxi, Abdelrahim, Maen, Vanderlaag, Kathryn, Liu, Xinyi, Porter, Weston, Metz, Richard, Safe, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234589/
https://ncbi.nlm.nih.gov/pubmed/18006642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0319
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