A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-κB activation

Nod1 and Nod2 are intracellular proteins that are involved in host recognition of specific bacterial molecules and are genetically associated with several inflammatory diseases. Nod1 and Nod2 stimulation activates NF-κB through RICK, a caspase-recruitment domain-containing kinase. However, the mecha...

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Autori principali: Hasegawa, Mizuho, Fujimoto, Yukari, Lucas, Peter C, Nakano, Hiroyasu, Fukase, Koichi, Núñez, Gabriel, Inohara, Naohiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234345/
https://ncbi.nlm.nih.gov/pubmed/18079694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601962
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