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A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-κB activation
Nod1 and Nod2 are intracellular proteins that are involved in host recognition of specific bacterial molecules and are genetically associated with several inflammatory diseases. Nod1 and Nod2 stimulation activates NF-κB through RICK, a caspase-recruitment domain-containing kinase. However, the mecha...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234345/ https://ncbi.nlm.nih.gov/pubmed/18079694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601962 |
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