RIP2 filament formation is required for NOD2 dependent NF-κB signalling

Activation of the innate immune pattern recognition receptor NOD2 by the bacterial muramyl-dipeptide peptidoglycan fragment triggers recruitment of the downstream adaptor kinase RIP2, eventually leading to NF-κB activation and proinflammatory cytokine production. Here we show that full-length RIP2 c...

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Publicado en:Nat Commun
Autores principales: Pellegrini, Erika, Desfosses, Ambroise, Wallmann, Arndt, Schulze, Wiebke Manuela, Rehbein, Kristina, Mas, Philippe, Signor, Luca, Gaudon, Stephanie, Zenkeviciute, Grasilda, Hons, Michael, Malet, Helene, Gutsche, Irina, Sachse, Carsten, Schoehn, Guy, Oschkinat, Hartmut, Cusack, Stephen
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168553/
https://ncbi.nlm.nih.gov/pubmed/30279485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06451-3
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