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Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel
The M2 protein of influenza A virus forms a transmembrane proton channel important for viral infection and replication. Amantadine blocks this channel, thus inhibiting viral replication. Elucidating the high-resolution structure of the M2 protein and its change upon amantadine binding is crucial for...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234170/ https://ncbi.nlm.nih.gov/pubmed/18230730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711500105 |
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