B-cell receptor activation inhibits AID expression through calmodulin inhibition of E-proteins

Upon encountering antigens, B-lymphocytes can adapt to produce a highly specific and potent antibody response. Somatic hypermutation, which introduces point mutations in the variable regions of antibody genes, can increase the affinity for antigen, and antibody effector functions can be altered by c...

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Bibliografiska uppgifter
Huvudupphovsmän: Hauser, Jannek, Sveshnikova, Natalia, Wallenius, Anders, Baradaran, Sanna, Saarikettu, Juha, Grundström, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2008
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234127/
https://ncbi.nlm.nih.gov/pubmed/18203819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708220105
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